Silylation derivatisation reagents

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REST35600 REST35601 REST35602 REST35603
Silylation derivatisation reagents
Kromatografi sorbenter GC Sorbenter
Silylation is the most widely used derivatisation procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group such as trimethylsilyl (TMS) or tert-butyldimethylsilyl (tert-BDMS). Silyl derivatives are more volatile, less polar, and more thermally stable. As a result, GC separation is improved and detection is enhanced.

  • Replace active hydrogen, reducing polarity and making the compounds more volatile
  • Increase stability of derivatives

Both TMS and tert-BDMS reagents are suitable for a wide variety of compounds and can be used for many GC applications.

Advarsel: Note that silylation reagents are generally moisture-sensitive and must be sealed to prevent deactivation.
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