Alum adjuvant, AlumVax hydroxideLeverandør: OZ Biosciences
Ratings: Ingen bedømmelse
OZBIAH0050EA 0 DKKOZBIAH0050 OZBIAH0250
Alum adjuvant, AlumVax hydroxide
Proteinekspressions Protein Ekspressionsreagenser
AlumVax hydroxide is a wet gel (colloidal) of aluminium hydroxide 2%. It is the most common adjuvant used in approved prophylactic vaccines because of its excellent safety profile and ability to enhance the protective humoral immune response.
- Ready to use suspension
- Store at room temperature
It has been observed that aluminium compounds act by a depot effect and also by direct activation of the immune cells. Adsorption or entrapment of antigens in aggregates through hydrophobic and electrostatic interactions favours a high local antigen concentration and improved uptake by antigen presentating cells (APC).
AlumVax hydroxide is a crystalline aluminium oxyhydroxide that is positively charged at physiological pH (pI=11), suitable for adsorption of negatively charged, acidic proteins (such as albumin). It stimulates Th2 response through the release of Th2-associated cytokines (IL4, IL-5, IL-13) and Th2-associated antibodies (IgG1 and IgE). It increases Ag-specific CD4+ T Cell proliferation and promotes NALP3 inflammasome activation and caspase 1-mediated release of IL-1 and IL-18.
Leveringsinformation: Shipped at room temperature.
Advarsel: Intended for research use only.