Anti-PDGFRA Rabbit Polyclonal Antibody

Leverandør: ProSci
Ratings: Ingen bedømmelse

Samlet vurdering
Gennemsntilig vurdering

PRSI49-775EA 4270 DKK
PRSI49-775
Anti-PDGFRA Rabbit Polyclonal Antibody
Antistoffer
PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. They possess five immunoglobulin like domains that are involved in ligand binding. Two tyrosine kinase domains are separated by a kinase insert to which PI-3 kinase can bind. PDGF AA can bind autophosphorylate and activate only PDGFR, alpha while PDGF BB can bind and activate to both PDGFR, alpha and beta. Platelet-derived Growth Factor Receptor Alpha (PDGFR alpha), a member of the a PDGF Receptor tyrosine kinase family, is a mediator of the biological actions of platelet-derived growth factor (PDGF). PDGF binding to PDGF receptors result in stimulation of cell growth, chemotaxis, and cell shape changes. Unlike PDGFR beta, PDGFR alpha can bind to both PDGF subunits. PDGFR alpha has been implicated in the development of spina bifida. In various mouse models, deregulated PDGFR alpha expression was found to result in congenital neural tube defects. In humans, various PDGFRA promoter haplotypes have been associated with neural tube defects.

PDGFRA antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL. Immunohistology (Formalin/paraffin) (Use Ab at 5-10 μg/mL for 30 min at RT) Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive Control Ovarian carcinoma Cellular Localization Cell membrane.

Protein A Column

PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type:
Antigen: PDGFRA
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
Bestil nu

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Læs mere About VWR