IKKbeta, an IKAPPAB-type protein kinase, is a member of the multimeric IkappaB kinase complex. This complex, often consisting of IKKalpha/IKKbeta heterodimers plus regulatory IKKgamma subunits, phosphorylates IkappaB proteins, marking them for destruction and thereby allowing activation of NFkappaB and downstream nuclear genes. The constitutively expressed IKKbeta protein contains an N-terminal kinase domain, a central leucine zipper motif, and a C-terminal helix-loop-helix motif. In knockout studies, IKKbeta (-/-) mice died between embryonic day 12.5 and 14 due to extensive liver damage from apoptosis; however, they were rescued by inactivation of the tumor necrosis factor receptor 1 gene. IKKbeta has been implicated in the pathogenesis of insulin resistance in obesity and type II diabetes mellitus.
IKBKB antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunoprecipitation
PBS. No preservative added.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Reactivity: Human, Mouse, Rat