Anti-ESR1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Leverandør: Bioss
Ratings: Ingen bedømmelse

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BOSSBS-0253R-A488EA 6410 DKK
BOSSBS-0253R-A488
Anti-ESR1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Antistoffer
Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ESR1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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