Anti-PSEN1 Mouse Polyclonal Antibody (Alexa Fluor® 488)

Leverandør: Bioss
Ratings: Ingen bedømmelse

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BOSSBS-0025M-A488EA 6410 DKK
BOSSBS-0025M-A488
Anti-PSEN1 Mouse Polyclonal Antibody (Alexa Fluor® 488)
Antistoffer
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1;PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Three alternative splice variants of PSEN1 have been identified.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: PSEN1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human, Rat, Rabbit
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