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Anti-HIF-PH2 Rabbit Polyclonal Antibody

Leverandør: Thermo Scientific
This antibody is expected to react with rat based on sequence homology. HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Type: Primary
Antigen: HIF-PH2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Specifikationer

Antigen symbol HIF-PH2
Antigen name HIF Prolyl Hydroxylase 2
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen synonyms C1ORF12 antibody, HIF Prolyl Hydroxylase 2, EGL 9 homolog of C. elegans 1 antibody, Chromosome 1 Open Reading Frame 12 antibody, EGLN 1 EGLN1 antibody
Gene ID 54583, 112405
Koncentration 1 mg/ml
Immunogen Synthetic peptide between amino acids 300-400 of the mouse HPH-2 protein.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.02% sodium azide
Opbevaringstemperatur 4° C, do not freeze
Shipping Temperature Ice

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