Anti-CD28 Human Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: CD28.2]

Leverandør: Tonbo Biosciences
Ratings: Ingen bedømmelse

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65-0289-T025EA 716 DKK
65-0289-T025
Anti-CD28 Human Monoclonal Antibody (Peridinin Chlorophyll/Cy5.5®) [clone: CD28.2]
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The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.

The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo (use format suitable for functional assays). This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus.

Type: Primary
Antigen: CD28 (CD28 molecule)
Clonality: monoclonal
Clone: CD28.2
Conjugation: Peridinin Chlorophyll/Cy5.5®
Epitope:
Host: Human
Isotype: IgG1 Kappa
Reactivity:
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